Stefano Tiziani

Research interests in my laboratory focus on translational chemical biology using a cutting-edge metabolomics-based systems biology approach for metabolic biomarker discovery. My laboratory combines i) high-throughput screening measurements, ii) magnetic resonance spectroscopy and mass spectrometry-based metabolomics, iii) metabolic flux analysis and iv) other omics data to gain a better bio-mechanistic understanding of the effects of combined drug treatment and nutrient modulation in cancer and non-cancer conditions. My current research is actively devoted to developing, integrating, and correlating high-throughput screening and untargeted metabolomics/lipidomics data to identify cancer vulnerabilities and accelerate the identification of novel synergistic combinatorial treatment measured in complex biological systems. 

Stefano Tiziani is an associate professor of Nutritional Sciences at The University of Texas at Austin (UTA) and holds courtesy appointments in the Department of Oncology and Department of Pediatrics at Dell Medical School. Additionally, he holds an adjunct position in the Department of Biochemistry and Structural Biology at The University of Texas Health Science Center at San Antonio. Dr. Tiziani is also a full member at the i) Institute for Cell and Molecular Biology (ICMB), UTA, ii) Center for Molecular and Cellular Toxicology (CMCT), College of Pharmacy, UTA, iii) Livestrong Cancer Institutes of the Dell Medical School, UTA, and iv) Cancer Therapy & Research Center (CTRC), Experimental and Developmental Therapeutics (EDT) program The University of Texas Health Science Center, San Antonio, Texas. 

Dr. Tiziani received his Laurea in chemistry at the University of Trieste in Italy and his Ph.D. at The Ohio State University. He completed postdoctoral training in metabolomics-based systems biology and molecular oncology at the University of Birmingham in the United Kingdom and Sanford-Burnham Medical Research Institute in La Jolla, California.

Dr. Tiziani has over 15 years of experience leading research projects focused on cancer metabolism and metabolite profiling using both mass spectrometry and nuclear magnetic resonance spectroscopy. His research primarily focuses on translational chemical biology, employing an innovative metabolomics-based systems biology approach to uncover metabolic biomarkers and design new combinatorial therapy strategies. His laboratory combines high-throughput screening measurements, magnetic resonance spectroscopy, mass spectrometry-based metabolomics, and metabolic flux analysis, alongside other omics data and computational data mining tools to monitor metabolic alterations and metabolic fluxes of stable isotope enriched tracers to probe cell metabolism following nutritional, drug and genetic perturbations. Presently, his research is dedicated to developing, integrating, and correlating high-throughput screening and untargeted metabolomics data to identify novel cancer vulnerabilities and accelerate the discovery of novel synergistic combinatorial treatments evaluated in cell lines and animal model systems and subsequently tested in clinical trials. 

His lab is constantly engaged in revealing the link between cellular pathways and biological mechanisms shaping our understanding of nutrition, chemical biology, physiology, and medicine.